ANHB1101 Lecture : lecture-notes-evolutionary-genetics

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Genetics of evolution o darwin descent with modification o today genetic change over time. Genetics of variation o within and between organisms. Study of the patterns and causes of genetic variation. In genetic terms, source of variation is a mutation (ie, change in the dna, producing an altered gene (allele) Evolution is a change in allele frequency (variation) over time. Genetic variation exists with and between organisms. There are different types of genetic variation (snp can result in synonymous or nonsynonymous changes) Human hapmap and 1000 genomes project is increasing our knowledge on genetic variation in different human populations. Changes in allele frequency can occur due to evolutionary forces. Tga (stop: length polymorphism (indel, copy number variation, chromosome inversion/genome duplication major shift in genome, results in death. Has two alleles: a (normal), s (sickle cell) this is called single cell variant lomoar cpsd| 7772177 if you have one copy of sickle cell allele you have resistance to malaria.

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