PHPR 2813 Study Guide - Rhinitis, Nasal Congestion, Allergic Conjunctivitis
7 Mar 2022
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Document Summary
Allergic rhinitis irritation or inflammation of nasal mucosa. High concentrations of serum ige (>100iu/ml) before age 6. Allergen-induced inflammation of nasal mucosa membrane mediated by ige. Atopic dermatitis usually comes first of the atopic diseases. No daycare attendance or late entry into nursery/preschool (4years older) Often goes undiagnosed due to being self-managed by patient with otc medications. Significant effects on the individual"s social life, productivity at work, and academic performance (~2 million missed school days/year in us) 80% diagnosed with ar develop symptoms before age 20. If one condition diagnosed, the other disease is suggested. Seconds minutes after initial exposure to allergen: mast cell degranulation rapid release of inflammatory mediators (histamine, leukotrienes, prostaglandin d2, tryptase, kinins, etc. ) Vasodilation, increased vascular/mucosal permeability, increased nasal secretions, pruritus, etc. Results in profound infiltration and activation of migrating cells (neutrophils, eosinophils, lymphocytes) Distinguished from other causes of rhinitis by thorough history from caregiver or patient including:
