PHPR 2813 Study Guide - Final Guide: Glucocorticoid, Hydrolase, Pneumonitis

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Drug-induced lung disease (dild): >350 prescribed meds reported to cause, all components of respiratory system are susceptible to insult. Angi to angii and also prevents the breakdown of bradykinin. Risk of cough w interchange to an arb- 0. 3: treatment: stop the drug, switch to arb dipyridamole, penicillamine, pentamidine, Iv heroin: opioid overdose, salicylate overdose, hctz, cocaine. Drug-induced pulmonary eosinophilia: pulmonary infiltrates with eosinophilia, clinical presentation fever, nonproductive cough, dyspnea, cxr bilateral pulmonary infiltrates. Labs remarkable for eosinophilia: tx: identify and stop causative drug. Drugs implicated in causing: chlorpropamide, cromolyn, methotrexate, nitrofurantoin *(acute rxn), pcn, sulfonamides, ttcn. ***time to onset of dz varies depending on causative drug; irreversible: pulmonary fibrosis one of the most serious drug. Presentation toxicities: nonproductive cough and exertional dyspnea, may or may not be associated with prior acute interstitial pneumonitis, associated with an excessive amount of connective tissue in interstitial spaces of the lungs proliferation/progressive accumulation. Scarring or fibrosis of lung parenchyma: >50 drugs implicated in causing.

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