PHPR 3823 Study Guide - Final Guide: Aids, Reverse Transcriptase, Tenofovir Alafenamide
7 Mar 2022
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Moa: inhibits reverse transcriptase of hiv-1 virus. Binds to hydrophobic pocket on reverse transcriptase. Human immunodeficiency virus (hiv: retrovirus that can cause acquired immunodeficiency syndrome (aids, leads to destruction of immune system, hiv viral categories, acts by binding to and then depleting cells. Hiv-1 that express cd4 (cluster designation4) receptors. Type most commonly found in u. s. a. and most of the world. Further divided into subtypes: b is most common in us. Transmission: occurs via infected body fluids, unprotected sexual activity with infected. Breast milk person: sharing needles with infected person, vertical transmission (mother to newborn, other body fluids may contain trace. During delivery amounts of hiv but have not been implicated in transmission. Transmission prevention: breastfeeding, occupational exposure (e. g. needle sticks), transfusion of infected blood products ** ** majority of cases were pre-1985: use a latex or polyurethane condom. Lambskin- not effective at std prevention: use only water-based lubricants (with latex, do not share needles or syringes .
