PHPR 3823 Study Guide - Final Guide: Peripheral Neuropathy, Staphylococcus Epidermidis, Diabetic Foot

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vmturner96

7 Mar 2022

School

Lipscomb University

Department

PHPR - Pharmacy Practice

Course

PHPR 3823

Professor

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Document Summary

Bedridden: hematogenous : seeding from primary infection in the blood occurs when bone tissue is seeded by the bacterial pathogen in the blood commonly affecting the long bones of children or vertebral osteo in those >50. Presentation : present several days to one week after onset of symptoms: monomicrobial, multiple bones in neonates. S. aureus: e. coli, group b strep, long bones in children (most common site) S. aureus / s. pneumoniae: vertebral (adults) : s. aureus / e. coli, ivda : s. aureus / gnrs (pseudomonas, blood cultures > 50% with positive cx in kids. Local spread from adjoining ssti; commonly from vascular insufficiency/neuropathy ex : cellulitis/ diabetic foot infxs: non-ambulatory, bed-ridden patients. Subtype: direct inoculation: occurs from trauma, surgery, prosthetic joints/hardware. Others strep / gnr (including pseudomonas) / Direct inoculation s. aureus / s. epidermidis / gnrs. Linezolid: trough goal : 15-20, dose : 15-20 mg/kg q 8-12, nephrotoxicity risk.

Related Questions

A patient with diabetes has a history of foot ulcer and, specifically, a recurrent diabetic foot infection (DFI). Despite treatment and apparent success of the treatment the infection continues to reappear. The initial microbiological investigation has identified Staphylococcus aureus in this infection. Diagnostic laboratory serotyping and clonal complex (CC) analysis has grouped this S. aureus isolate with S. aureus strains that actually are more commonly isolated from patients with respiratory infections. Further simple analysis by PCR has revealed the presence of non-typical virulence factors. Describe a research plan you would undertake to identify the molecular mechanisms (that is: the surface structures, the metabolic pathways and the stress response pathways) used by this specific S. aureus isolate for its colonization, persistence, and to act as a recurrent cause of DFI disease.

Describe a research plan you would undertake to identify the molecular mechanisms (that is: the surface structures, the metabolic pathways and the stress response pathways) used by this specific S. aureus isolate for its colonization, persistence, and to act as a recurrent cause of DFI disease.

Clostridium difficile is a Gram-positive entericpathogen that is a significant concern in hospital settings due toresistance to many types of antibiotics. A healthy individual cannormally resist infection by this pathogen, but under certainconditions an individual can become infected and develop severecolitis that can be life-threatening. One such condition istreatment of patients with broad-spectrum antibiotics.

A. Given that infection by this pathogen occurs under certainconditions, such as broad-spectrum antibiotic treatment, how wouldyou characterize this pathogen? (3 points)

B. Other factors that may contribute to developing C.difficile infection are changes in the gastrointestinal florawith age or disease, gastrointestinal surgery and use ofantiperistaltic drugs. Why do you think these factors influenceC. difficile infection? You donât have to explain eachfactor individually, just think about the common basis of thesefactors. Hint: think about the human relationship with the majorityof microbes in the gut. (7 points)

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PHPR 3823 Study Guide - Final Guide: Peripheral Neuropathy, Staphylococcus Epidermidis, Diabetic Foot

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