MEDICINE : DISEASES INVOLVING RED BLOOD CELLS-Pernicious anemia,thalassemia-erythroblastosis fetalis,sicklecell anemia,iron deficiency anemia,aplastic anemia,polycythemia vera
9 Nov 2022
Department
Course
Professor
Document Summary
Pernicious anemia is a relatively common chronic hematologic disease. It is an adult form of anemia that is associated with gastric atrophy and a loss of intrinsic factor production in gastric secretions. The term pernicious anemia is reserved for patients with vitamin b12 deficiency due to a lack of production of if in the stomach. Intrinsic factor in gastric secretions is necessary for the absorption of dietary vitamin b12. Pernicious anemia probably is an autoimmune disorder with a genetic predisposition and the disease is associated with human leucocyte antigen (hla) types a2, a3, and b7 and a blood group. A greater association than anticipated exists between pernicious anemia and other autoimmune diseases, which include thyroid disorders, type i diabetes mellitus, ulcerative colitis, addison disease, and acquired agammaglobulinemia. Pernicious anemia is rare before the age of 30 years and increases in frequency with advancing age. The disease is often characterized by the presence of a triad of symptoms:
