Question

a) List the characteristic features of autosomal dominant inheritance. How might reduced penetrance obscure this mode of inheritance in a pedigree?

b) Describe two molecular mechanisms that can give rise to autosomal dominant alleles, and describe an example of each.

c) List the characteristic features of mitochondrial inheritance. Explain why mitochondrial disorders typically demonstrate both variable expressivity and delayed onset after birth.

d) List the characteristic features of X-linked recessive patterns of inheritance. Describe circumstances in which the daughter of an affected male may display clinical features of the disorder.