1
answer
0
watching
98
views
22 May 2018
1. How many and which residues of Isocitrate dehydrogenase (IDH) bind with NADP+?
a) What are interaction with which atom of NADP+?
b) What is the distance between these atoms?
c) Are there any secondary structural context?
2. Write a proposed mechanism for IDH-catalyzed reaction. Include at least 3 residues that are involved in such a mechanism, and briefly explain what each is doing (e.g. acting as acid/base at a specific step, stabilizing a specific intermediate state, etc..)
1. How many and which residues of Isocitrate dehydrogenase (IDH) bind with NADP+?
a) What are interaction with which atom of NADP+?
b) What is the distance between these atoms?
c) Are there any secondary structural context?
2. Write a proposed mechanism for IDH-catalyzed reaction. Include at least 3 residues that are involved in such a mechanism, and briefly explain what each is doing (e.g. acting as acid/base at a specific step, stabilizing a specific intermediate state, etc..)
Patrina SchowalterLv2
24 May 2018