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2 Mar 2018

Which of the following would you predict with iodine deficiency?

Low TH; Low TRH and TSH

High TH, High TRH and TSH

High TH, Low TRH and TSH

Low TH, High TRH and TSH

Low TH; Low TRH and TSH

I thought it was low TH; low TRH and TSH but that was incorrect. Can someone explain why it's incorrect and what the correct answer is?

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Keith LeannonLv2

2 Mar 2018

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Question 7 (1 point)

You are working with a transcription factor protein and genetically remove the only helix-turn-helix domain in it. What is likely to happen?

Question 7 options:

	The transcription factor no longer works as it does not bind DNA
	The transcription factor works more efficiently as HTH domains inhibit DNA binding
	The transcription factor is unable to release DNA due to loss of HTH
	The transcription factor does not interact with its co-activator.

Question 8 (1 point)

Under which of the following conditions would the lac operon be active.

Question 8 options:

	low glucose, high lactose
	high glucose, high lactose
	low glucose, low lactose
	high glucose, low lactose

9. Which of the following best represents the systemic arterial blood of an individual with anemia?

A. Low PO2, low hemoglobin, low O2 content

B. Low PO2, low hemoglobin, normal O2 content

C. Low PO2, normal hemoglobin, low O2 content

D. Low PO2, normal hemoglobin, normal O2 content

E. Normal PO2, low hemoglobin, low O2 content this is the correct answer but what would be the arterial hemoglobin saturation be with individuals with anemia?I need to explain for this!

F. Normal PO2, low hemoglobin, normal O2 content

G. Normal PO2, normal hemoglobin, low O2 content

H. Normal PO2, normal hemoglobin, normal O2 content

Key: A.Increase

B.Decrease

C. Remain thesame

For questions 19-20 use the following information Thyroid-stimulating hormone (TSH) is secreted from the anterior pituitarygland and acts on the thyroid gland to increase the secretion ofthyroid hormones. Thyroid hormones, on the other hand, have anegative-feedback effect on TSH secretion (See Fig. 16.8 in yourtext). For a person having normal thyroid function, the rate atwhich TSH and thyroid hormones are secreted remains within a normalrange of concentrations. In some people, however, the immune systembegins to produce an abnormal substance that functions likeTSH.

Predict what that substance will do to:

19. _____the rate of thyroid stimulating hormone secretion

20. _____ the rate of thyroid hormone secretion.

For question 21 use the following information. Background:Hormones are dissolved in blood plasma and transported either in afree form or bound to plasma proteins. Hormones that are lipidsoluble, such as steroids and thyroid hormone, circulate in theblood in combination with these plasma proteins. Hormones that bindto plasma proteins do so in a reversible fashion according to theequation:

H + BP <-----------> HBP

(Hormone) (BindingProtein) (Hormone bound to binding protein)

An equilibrium is established between the free plasma proteinsand the hormones bound to the plasma proteins. This equilibrium isimportant because only a free hormone is able to diffuse throughcapillary walls and bind to target cells. The combination of ahormone bound to a binding protein reduces the rate at which theydiffuse through the walls of capillaries.

This increases the half-life of the hormone. The half-life isthe length of time it takes to eliminate half a dose of a substancefrom the circulatory system. The half-life of a hormone is astandard measurement used by endocrinologists because it allowsthem to predict the rate at which a given hormone will beeliminated from the body.

21. _____How is the half-life of a hormone affected by adecrease in the concentration of the

specific plasma protein to whichthat hormone binds? Remember if the time to

eliminate a hormone from theblood stream is longer then the half life has increased.

If the time to eliminate ahormone shortens then the half life has decreased

22. _____Consider a hormone that is secreted in large amounts ata given interval, modified

chemically by the liver, andexcreted by the kidney at a rapid rate, making the

half-life of the hormone in thecirculatory system very short. The hormone therefore

rapidly increases in the bloodand then decreases rapidly. Predict the

consequences of liver and kidneydisease on the blood levels of that hormone.

For question 23 use the following background information:Periodic increases in the sensitivity of some tissues to certainhormones is called up-regulation. It results from an increase inthe rate of receptor molecule synthesis. In many tissues the numberof hormone receptors rapidly decreases after exposure to certainhormones. This is called down-regulation.

Problem. Estrogen is a hormone secreted by theovary. It is secreted in greater amounts after menstruation and afew days before ovulation. Among its many effects is causing

up-regulation of receptors in the uterus for another hormonesecreted by the ovary called progesterone. Progesterone is secretedafter ovulation. A major effect of progesterone is to cause theuterus to become ready for the embryo to attach to its wallfollowing ovulation. Pregnancy cannot occur unless the embryoattaches to the wall of the uterus.

23. ______Predict the consequences on becoming pregnant if theovary secretes too little

estrogen?

24. ______ Predict the effect of inadequate dietary intake ofcalcium on PTH secretion

25. ______ Predict the effect of inadequate dietary intake ofcalcium on Calcitriol secretion

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