Question

Case study help. What might they have?

a). 10-year-old female. complaints of lethargy and leg pain.Splenomegaly and lymphadenopathy present in physical exam. WBC: 6.5× 10^9/L; Hb: 8 g/dL; Platelet: 21× 10^9/L

Peripheral blood smear revealed –Predominance of very young blood cells (blasts)

• These cells are normally found only in the BM

BM examination

100% cellularity (red marrow)

Predominance of the same type of blasts that were seen in the peripheralblood

Question 1: Describe Francine's BM as normal, hyerplastic, orhypoplastic.

Question 2: What condition can cause this bone marrowfinding?

Question 3: What do you think is the cause of thesplenomegaly?

Question 4: Why might the peripheral blood reveal changes associated with hyposplenismwhen

the spleen is enlarged?

Question 5: What might explain the lymphadenopathy?

I am assuming she has leukemia of the lymphocytic cells, but Ineed help understanding these questions please.