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14. How do 5fluorodeoxyuridine monophosphate and methotrexate affect cellmetabolism? Know the specific enzymes affected and theconsequences for the cell.

15.what do adenosinedeaminase, 5

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Sixta Kovacek
Sixta KovacekLv2
28 Sep 2019

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Related questions

You have two different mutant cell lines. Both cell line A and cell line B do not grow in a medium containing hypoxanthine, thymidine, and a cytotoxic amount of methotrexate. However, cell line C, which is formed by the fusion of cell lines A and B, grows in this medium even though the methotrexate is still in the growth medium. What is the biochemical basis for this observation? (4 points).

How does temperature affect enzyme activity? SPECIFICALLY what happens at low temperatures? Why do we store enzymes in the freezer? What is the “optical temperature” of an enzyme? Approximately what might this temperature be for human enzymes (in Celcius!)? Approximately what might be the optimal temperature for the fungus that grows on the food that you forget about in the back of the refrigerator?

What is competitive inhibition? How do competitive inhibitors affect enzyme activity?

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Given what you know about the relationship between the structure and function of enzymes, what specific aspects of protein structure are affected by the two types of competitors? Explain using the terminology that you learned about the levels of protein structure.

4. Mary has beentaking methotrexate for about 4 months (along with naproxen asneeded). She is currently taking 15mg weekly but her RA is notunder control yet and she been feeling really rough the past fewdays with a sore throat and a cough developing. It’s the weekendand she can’t reach her rheumatologist so she stops at yourpharmacy. Should she stop taking MTX?

5. Mary (above) is takingirregular doses of naproxen with her methotrexate. Is that aproblem? If so, how should it be managed?

6. You have apatient in the pharmacy who just began her first prescription for abiologic (Actemra). She asks how quickly it will work. She is alsovery worried about the risks of medication itself, whether she willrun out of options to control her disease, and if she must be onmedication for life. Please describe the information you will giveto counsel her, both to make her well informed and to calm herfears.

7. Assume you havea patient who originally had mild RA for two years. She has takenmethotrexate and etanercept for one year and been in full remissionnow for 6 months. Should we stop her drug treatment? What exactlyshould you recommend?

8. Another patientwas on methotrexate orally, but now her doctor wants to switch tothe injection form and the patient is upset about it. What are thepossible advantages to sc. injection?

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