1. Gennie is wild type. Below is a segment of her DNA. The topstrand is the coding region, and the reading frame begins with thefirst codon that codes for met (start codon).
5' GCATGTTCTTGT 3'
3' CGTACAAGAACA 5'
Kevin is mutant. Below is a segment of his DNA. The top strandis the coding region, and the reading frame begins with the firstcodon that codes for met (start codon).
5' GCATGTTTTTGT 3'
3' CGTACAATAACA 5'
What type of mutation does Kevin have?
A) silent
B) misssense
C) nonsense
D) frameshift
2) A type of dwarfism results from the production of mutantSHR-1 protein. You look at the length of the mutant SHR-1 and thenormal (wild-type) SHR-1 protein, and discover that the mutantSHR-1 protein has fewer amino acids.
What do you expect to find when you examine the DNAsequence?
A) nucleotides were deleted
B) additional nucleotides were added
C) one nucleotide was changed
D) without additional information, any of the above arepossible.
3) Below are two DNA coding strand sequences. The 5' ATG encodesthe in-frame strat codon.
Tom's DNA sequence is:
5' ATG CGC TTA CCC TTA CTC CTA TAA 3'
Harry's DNA sequence is:
5' ATG CGC TAA CCC TTA CTC CTA TAA 3'
Harry's mutation causes the premature termination of:
A) Replication
B) Transcription
C) Translation
D) Answer B and C
E) All of the above
1. Gennie is wild type. Below is a segment of her DNA. The topstrand is the coding region, and the reading frame begins with thefirst codon that codes for met (start codon).
5' GCATGTTCTTGT 3'
3' CGTACAAGAACA 5'
Kevin is mutant. Below is a segment of his DNA. The top strandis the coding region, and the reading frame begins with the firstcodon that codes for met (start codon).
5' GCATGTTTTTGT 3'
3' CGTACAATAACA 5'
What type of mutation does Kevin have?
A) silent
B) misssense
C) nonsense
D) frameshift
2) A type of dwarfism results from the production of mutantSHR-1 protein. You look at the length of the mutant SHR-1 and thenormal (wild-type) SHR-1 protein, and discover that the mutantSHR-1 protein has fewer amino acids.
What do you expect to find when you examine the DNAsequence?
A) nucleotides were deleted
B) additional nucleotides were added
C) one nucleotide was changed
D) without additional information, any of the above arepossible.
3) Below are two DNA coding strand sequences. The 5' ATG encodesthe in-frame strat codon.
Tom's DNA sequence is:
5' ATG CGC TTA CCC TTA CTC CTA TAA 3'
Harry's DNA sequence is:
5' ATG CGC TAA CCC TTA CTC CTA TAA 3'
Harry's mutation causes the premature termination of:
A) Replication
B) Transcription
C) Translation
D) Answer B and C
E) All of the above
Related textbook solutions
Related questions
Match the following:
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Part B
Think about the DNA coding sequence of a gene. If an A were swapped for a T, what kind of mutation could it cause and why?
| a) It could cause a frameshift nonsense or frameshift missense mutation because it would change the reading frame of the codon triplet. | ||||||||||||||||||||||||||||
| b) It could cause a silent, missense, or nonsense mutation because those are the types that can be caused by a nucleotide-pair substitution like this one. | ||||||||||||||||||||||||||||
| c) It could cause a nonsense mutation because the sequence would no longer be the same, so the protein would be shorter and non-functional. | ||||||||||||||||||||||||||||
| d) It could cause a silent mutation because A and T are complementary to each other so it is not really a substitution mutation. Part C Why is a frameshift missense mutation more likely to have a severe effect on phenotype than a nucleotide-pair substitution missense mutation in the same protein?
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