1. The RAS proteinacquires a mutation that prevents release of GTP. Which of thefollowing characteristics are these cells likely toacquire?
A. Self-Sufficiency in growth signals
B. Insensitivity to anti-growth signals
C. Metastasis
2. Which of the following genes would you suspect to bea tumor supressor?
A. MSH2
B. CDK2
C. c-myc
3. A gene that is involved in a normal cellular processesbut when mutated contribute to cancer developmentis:
A. a proto-oncogene
B. a housekeeping gene
4. When a person carries a mutation in a tumor suppressorgene on one-chromosome and subsequently loses function of theirwildtype tumor suppressor allele, this describes:
A. gene conversion to an oncogene
B. loss of heterozygosity
C. haploinsufficiency
5. The mechanism by which alterations in DNA methylationcould promote carcinogenesis is:
A. by lengthening telomeres
B. by interacting with reactive oxygen species and thereforebecoming a potent mutagen
C. by either repressing or enhacing gene expression
6. When anaylzing a cell you find that it has aninactivating mutation in p53 and a mutation in the VEGF receptorthat makes activation independent of ligand binding. Which of thefollowing hallmarks would you expect the cell toexhibit?
I. self-sufficiency in growth
II. insensitivit to anti-growith signals
III. limitless replicative potential
IV. evading apoptosis
V. sustained angiogenesis
A. IV and V only
B. II, III, VI
C. I and III only
1. The RAS proteinacquires a mutation that prevents release of GTP. Which of thefollowing characteristics are these cells likely toacquire?
A. Self-Sufficiency in growth signals
B. Insensitivity to anti-growth signals
C. Metastasis
2. Which of the following genes would you suspect to bea tumor supressor?
A. MSH2
B. CDK2
C. c-myc
3. A gene that is involved in a normal cellular processesbut when mutated contribute to cancer developmentis:
A. a proto-oncogene
B. a housekeeping gene
4. When a person carries a mutation in a tumor suppressorgene on one-chromosome and subsequently loses function of theirwildtype tumor suppressor allele, this describes:
A. gene conversion to an oncogene
B. loss of heterozygosity
C. haploinsufficiency
5. The mechanism by which alterations in DNA methylationcould promote carcinogenesis is:
A. by lengthening telomeres
B. by interacting with reactive oxygen species and thereforebecoming a potent mutagen
C. by either repressing or enhacing gene expression
6. When anaylzing a cell you find that it has aninactivating mutation in p53 and a mutation in the VEGF receptorthat makes activation independent of ligand binding. Which of thefollowing hallmarks would you expect the cell toexhibit?
I. self-sufficiency in growth
II. insensitivit to anti-growith signals
III. limitless replicative potential
IV. evading apoptosis
V. sustained angiogenesis
A. IV and V only
B. II, III, VI
C. I and III only
