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Given their modes of inheritance, and assuming Mendelian inheritance, if a heterozygote carrier for BRCA1 (autosomal dominant) and TP53 (autosomal recessive) mated with another heterozygote carrier for BRCA1 and TP53, what is the probability of them having a child that has breast cancer, but doesn’t have adrenal cortical carcinoma?

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Sixta Kovacek
Sixta KovacekLv2
29 Sep 2019

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Related questions

When someone is said to have inherited a predisposition to cancer, what is meant by that?

There is a germ-line mutation

The gene involved shows incomplete penetrance

The disorder has variable expressivity

There is a somatic mutation

Imagine you observe the following in a data set: more males affected than females; approximately half the grandsons of affected males are affected; some females are affected but usually only if their maternal grandfather was affected and their mother married an affected male. What type of inheritance might you suspect?

sex-linked recessive

autosomal dominant,sex-limited

sex-linked dominant

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A cross of fruit flies was conducted. White-eyed males were cross with pink-eyed females. All F1 flies had normal eye color. F1’s were intercrossed yielding F2 flies as follows: 890 wildtype females, 455 wildtype males, 605 white-eyed males, 140 pink-eyed males, and 310 pink-eyed females. Give a genetic explanation consistent with these data.

white is autosomal recessive and epistatic to pink

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Based on what you know about translation, what does “reverse translation” mean?

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Determining a RNA sequence from a DNA sequence

Translating in the 3’ to 5’ direction

Transcribing first, then translating

Type 1 Gaucher disease is a rare disorder resulting from not having enough glucocerebrosidase, an important enzyme that breaks down a fatty chemical called glucocerebroside. It is caused by an autosomal recessive allele and the disease is most common in population groups in which consanguineous marriage is not unusual. A woman is married to her first cousin, and the couple is planning to have a child, but discovers that their shared grandmother’s brother suffered from type 1 Gaucher disease (assume others in the family don’t have Type 1 Gaucher disease).

1. Draw the relevant parts of the pedigree (starting from the couple’s shared great grandparents).

2. What is the probability that the couple’s first child will have Type 1 Gaucher disease, assuming that all people who marry into the family are homozygous for the normal allele?

3. If the couple’s first child turns out to have type 1 Gaucher disease but the second child does not have it, what is the probability that their second child is a carrier?

Sample questions from a past test on Mendelian Genetics

1)A woman and her spouse both show the normal phenotype for pigmentation, but both had one parent who was an albino. Albinism is an autosomal recessive trait.
What is the probability that their fourth child will have a homozygous genotype?
a. 0 b. 1?4 c. 1?2 d. 3?4. e. 1

2)Black fur in mice (B) is dominant to brown fur (b). Short tails (T) is dominant to long tails (t). What fraction of the progeny (offspring) of the cross BbTt X BBtt will have black fur and long tails?
a. 1/16 b. 3/16 c. 3/8 d. 1?2 e. 9/16

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