Identify amino acids which when being part of a protein structure have side chains that can participate in the hydrogen bond formation. Draw the structure of each amino acid and indicate how it can form the hydrogen bonding.
2. Identify amino acids which when being part of a protein structure have side chains that can participate in chemical reactions. Explain why and how. For instance which residues are used for post-translational modifications, for regulation of protein activity, how are glycans and lipids attached to proteins?
3. Identify amino acids which when being part of a protein structure have side chains that can ionize or are charged at pH 7. Based on the pKR values of the free amino acids estimate/calculate what percentage of the amino acid is in the charged form.
Explain why some amino acids, like serine in serine proteases, can ionize/lose proton at neutral pH while their pKR values suggest that this should not be possible.
Identify amino acids which when being part of a protein structure have side chains that can participate in the hydrogen bond formation. Draw the structure of each amino acid and indicate how it can form the hydrogen bonding.
2. Identify amino acids which when being part of a protein structure have side chains that can participate in chemical reactions. Explain why and how. For instance which residues are used for post-translational modifications, for regulation of protein activity, how are glycans and lipids attached to proteins?
3. Identify amino acids which when being part of a protein structure have side chains that can ionize or are charged at pH 7. Based on the pKR values of the free amino acids estimate/calculate what percentage of the amino acid is in the charged form.
Explain why some amino acids, like serine in serine proteases, can ionize/lose proton at neutral pH while their pKR values suggest that this should not be possible.