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29 Sep 2019
Question 3 (8 points)
Consider the following mutations and, for each, explainwhether
a) you expect it to be potentially promotingcancer AND
b) you expect it to be a dominant or recessivemutation.
i) A mutation that destroys the active site ofan enzyme necessary to promote cell cycle
a)
b)
ii) A very premature STOP codon in a geneencoding a protein involved in the excision-repair mechanism
a)
b)
iii) A point mutation that rendersconstitutively active one of the signaling proteins in the Raspathway
a)
b)
iv) A null mutation in a gene encoding anapoptotic (apoptosis-promoting) protein
a)
b)
Question 3 (8 points)
Consider the following mutations and, for each, explainwhether
a) you expect it to be potentially promotingcancer AND
b) you expect it to be a dominant or recessivemutation.
i) A mutation that destroys the active site ofan enzyme necessary to promote cell cycle
a)
b)
ii) A very premature STOP codon in a geneencoding a protein involved in the excision-repair mechanism
a)
b)
iii) A point mutation that rendersconstitutively active one of the signaling proteins in the Raspathway
a)
b)
iv) A null mutation in a gene encoding anapoptotic (apoptosis-promoting) protein
a)
b)
Lelia LubowitzLv2
29 Sep 2019
