Select the correct order of events (1-10) for the signal transducon pathway iniated by the EGF receptor. (place the number 11 for those which are not applicable).
_____ MEK is phosphorylated by RAF.
____ The receptor undergoes a conformaonal change.
_____ The second messengers IP3 and DAG are produced.
_____ The cytoplasmic tail of the receptor is phosphorylated.
_____ An adaptor protein binds to the phosphotyrosine residues, recruing SOS and Ras.
_____ MEK is phosphorylated by ERK.
_____ RasGAP stimulates GTPase activity of Ras which returns to the GDP bound state.
_____ ERK is phosphorylated by MEK.
_____ The Galpha subunit dissociates from Gbeta/Ggamma.
_____ ERK enters the nucleus and smulates cell proliferaon.
_____ The receptor dimerizes acvang its tyrosine kinase acvity.
_____ The Galpha subunit binds to Phospholipase C.
____ Epidermal growth factor binds to the receptor.
_____ Ras is phosphorylated by RAF.
____ The Galpha protein releases GDP and binds GTP.
____Glucagon binds to the receptor.
Select the correct order of events (1-10) for the signal transducon pathway iniated by the EGF receptor. (place the number 11 for those which are not applicable).
_____ MEK is phosphorylated by RAF.
____ The receptor undergoes a conformaonal change.
_____ The second messengers IP3 and DAG are produced.
_____ The cytoplasmic tail of the receptor is phosphorylated.
_____ An adaptor protein binds to the phosphotyrosine residues, recruing SOS and Ras.
_____ MEK is phosphorylated by ERK.
_____ RasGAP stimulates GTPase activity of Ras which returns to the GDP bound state.
_____ ERK is phosphorylated by MEK.
_____ The Galpha subunit dissociates from Gbeta/Ggamma.
_____ ERK enters the nucleus and smulates cell proliferaon.
_____ The receptor dimerizes acvang its tyrosine kinase acvity.
_____ The Galpha subunit binds to Phospholipase C.
____ Epidermal growth factor binds to the receptor.
_____ Ras is phosphorylated by RAF.
____ The Galpha protein releases GDP and binds GTP.
____Glucagon binds to the receptor.