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19 Apr 2019

A 21-year-old woman presents with a 3-month history of malaise,joint pain, weight loss, and sporadic fever. Her temperature is38°C (101°F). The serum antinuclear antibody (ANA) test is positive(1:640). Corticosteroids are prescribed to suppress the patient'simmune system. Death of post-thymic lymphocytes induced bycorticosteroid therapy is characterized by fragmentation of DNA,which can be detected by gel electrophoresis in the form of a“ladder.” This finding represents sequential cleavage of which ofthe following cellular components?
Question options:

A) Centrosomes
B) Kinetochores
C) Nucleoli
D) Nucleosomes

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