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17 Nov 2019
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Provide mechanisms for all steps of the following sequences of reactions. Until this last week, you had never learned a way to synthesize any aromatic molecules (even though we didn't explicitly discuss it in lecture). The following reaction, called the Debus-Radziszewski imidazole synthesis, is a useful and common way to make substituted imidazoles. Provide a complete mechanism for all steps. Imidazoles can be further functionalized to produce a metronidazole analog. (Metronidazole is an antibiotic on the World Health Organization's List of Essential Medicines.) Provide mechanisms for all steps. As you learned in E-2a, trans alkenes are generally more stable than their cis diastereomers. The two-step sequence shown below stereosepecifically converts trans to cis alkenes, making use of the unique oxophilicity of phosphorus. Show a curved-arrow mechanism for the following sequence of reactions, making sure that your drawings clearly account for the observed stereochemistry.
Will rate promptly please help!
Provide mechanisms for all steps of the following sequences of reactions. Until this last week, you had never learned a way to synthesize any aromatic molecules (even though we didn't explicitly discuss it in lecture). The following reaction, called the Debus-Radziszewski imidazole synthesis, is a useful and common way to make substituted imidazoles. Provide a complete mechanism for all steps. Imidazoles can be further functionalized to produce a metronidazole analog. (Metronidazole is an antibiotic on the World Health Organization's List of Essential Medicines.) Provide mechanisms for all steps. As you learned in E-2a, trans alkenes are generally more stable than their cis diastereomers. The two-step sequence shown below stereosepecifically converts trans to cis alkenes, making use of the unique oxophilicity of phosphorus. Show a curved-arrow mechanism for the following sequence of reactions, making sure that your drawings clearly account for the observed stereochemistry.
Elin HesselLv2
26 Feb 2019