Question

Which of the follow regulate oxidative phosphorylation underhypoxic conditions? There are 3 statements that are correct.

A) HIF-1 replaces a subunit of Complex IV of the electrontransport chain with a subunit that is more efficient under hypoxicconditions.

B) Pyruvate dehydrogenase (PDH) kinase phosphorylates PDH,inactivating it and reducing the availability of electron carriersto the electron transport chain.

C) The protein inhibitor IF1 binds two ATP synthase moleculesand inhibits their ATPase activity.

D) ATP synthaase converts ATP to ADP, raising [ADP] to increasethe rate of oxidative phosphorylation.

E) High pyruvate concentrations increase pH above 6.8,stabilizing the inhibitory IF1 dimer and preventing ATPhydrolysis.