PCOL2011 : PCOL2011 complete drug list, description & mechanismsNew

• School: University of Sydney
• Department: Pharmacology
• Course: PCOL2011
• Professor: All

Document Summary

Augmentin stable to acid, lactamase and good ratio of activity against gram positive/negative bacteria: cephalexin is structurally modified from cephalosporin c broad spectrum, belongs to monobactams, resistant to lactamase, belongs to carbapenems, resistant to lactamase, large bulky side group so does not fit into lactamase, but still reaches required active site, not stable to acid, combination of amoxicillin and clavulanic acid, clavulanic acid is an lactamase inactivator. Intercalates with dna like proflavine amino group gives ionic bonding to phosphates: analgesic; pka 8. 2, binds to carboxylate, glutamate through nh2+ and ach through quaternary ammonium, binds to guanidinium group on argnine with carboxylate, trimfluromethyl group imparts large dipole dipole dipole intermolecular force. Ionic bonding since you are inactivating gates: las, benzocaine does not have an amino group so low solubility, cocaine has vasoconstrictor properties, clove oil, antiseptic, zno eugenol as temporary dental filling.