300905 Study Guide - Final Guide: Dna Damage (Naturally Occurring), Helicobacter Pylori, Stomach Cancer
23 Feb 2020
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Document Summary
Dna damage is considered to be the primary underlying cause of malignant neoplasms known as cancers. Naturally occurring dna damages (mostly due to cellular metabolism and the properties of dna in water at body temperatures) occur at a rate of more than 60,000 new damages, on average, per human cell, per day. Additional dna damages can arise from exposure to exogenous agents. Tobacco smoke causes increased exogenous dna damage, and these dna damages are the likely cause of lung cancer due to smoking. Uv light from solar radiation causes dna damage that is important in melanoma. Helicobacter pylori infection produces high levels of reactive oxygen species that damage dna and contributes to gastric cancer. Bile acids, at high levels in the colons of humans eating a high fat diet, also cause dna damage and contribute to colon cancer. Some sources of dna damage are indicated in the boxes at the top of the figure in this section.
