IMED1001 Study Guide - Final Guide: Equilibrium Constant, Membrane Transport Protein, Facilitated Diffusion
Document Summary
Rate limited by speed of each carrier and total number of carriers. Solute concentration ([x]) at which jx is half of the maximal flux (jmax). The higher the apparent affinity of the transporter for the solute. Fixed number of membrane bound carriers for each solute. Limited speed at which the carrier can operate. Carry solutes from one side of a membrane to the other. Solutes bind to specific sites on the carrier. Rocking of protein from one conformation to another. Opens to other side of membrane where solute can release. Carriers work equally well in both directions. Transport rate "saturates" or limits at higher concentrations. Transport rate can be reduced by competition for binding sites. They can be "blocked" pharmacologically by specific drugs & toxins. Transport a single solute from one side of the membrane to another. Transfer of one solute depends on the simul- taneous transport of a second solute (coupled transport).
