IMED2004 Study Guide - Final Guide: Microtubule, Cytoskeleton, Homeobox
Document Summary
Bcd mrna tethered to ends of microtubules. Hb-m protein gradient depends on nanos protein. Nanos mrna tethered to + end of microtubule via 3"utr. Nanos protein gradient blocks translation of hb-m. Maternal bicoid mrna is packaged into head of developing embryo. Maternal nanos mrna is packaged into tail of developing embryo. Mrnas tethered to cytoskeleton at poles of embryo. Expressed in embryo to form a protein gradient. And the expression of other genes respond to particular [tf] Caudal is a fourth maternal product crucial in posterior end axis formation. But a-p gradient formed due to inhibition of caudal protein synthesis. By bicoid which binds 3" utr of caudal mrna. So bicoid is not acting as tf in this case. Caudal last to starts to set up anterior posterior gradient. Caudal mrna evenly distributed in egg, no tethered. Formed because inhibition of caudal by bicoid. Caudal low at end that has high bicoid.
