IMED2004 Study Guide - Final Guide: Encode, Human Genome, Outcrossing
Document Summary
Human epigenome project aimed to identify, catalogue and interpret genome-wide dna methylation patterns of all human genes in all major tissues. International human epigenome project (ihep) decipher at least 1000 epigenomes within 7-10 years. Entire catalogue of and expression of non-coding and rnas. Encode project began as a pilot project on 1% of the genome. In 2007 the effort was scaled to whole-genome assays. Followed by expansion to similar assays in mouse. Project continues to create a comprehensive catalog of gene elements and functional elements in the human and mouse genomes by: Identifying proteins that interact with rna and dna (e. g. modified histones, transcription factors & rna-binding proteins). Measuring the levels of dna methylation, and identifying regions of dna hypersensitivity. Processes that lead to changes in genetic composition. Mating may be random or assortative and may involve inbreeding or outbreeding. Random fluctuation in reproductive rates may result in genetic drift in allele frequencies.
