IMED2004 Study Guide - Final Guide: Allele Frequency, Mutation Rate, Gamete
Document Summary
Probability of a gene mutating during or between dna replications. The number of events that produce mutated alleles per locus per generation. Mutation rate defined as probability that a copy of an allele changes to another allelic form in one generation. Increase in frequency of a mutant allele will be product of the mutation rate times the frequency of the non-mutant allele. Mutations to a occurred at rate of 1/100,000 per gamete. Freq. of a would only be 1. 0 x 1/100,000. = 0. 00001 and freq of a would be 0. 99999. Freq. of a would be increased by 0. 99999 x 1/100,000. = 0. 000009 to a new freq of 0. 000019 and frequency of a would be decreased to 0. 999981. Consider mutation of an allele a to another allele a. Still only have 10% a alleles after 10,000 generations at this high mutation rate. Mutation is the source of genetic variation.
