IMED2004 Study Guide - Final Guide: Abo Blood Group System, Epistasis, Pleiotropy
Document Summary
Inheritance of multiple alleles, including abo blood groups. Gene interaction & epistasis, with emphasis on recessive epistasis. Whose experiments in breeding garden peas led to his eventual recognition as founder of the science of genetics. Mendel determined that an individual possesses two alleles for a trait. But that only one is displayed (the dominant one) So the heterozygote has the same phenotype as the homozygote (dominant). Mendel knew this was not always the case. He had crossed plants where flowering times differed & found an intermediate phenotype. So, mendel"s principles alone don"t explain inheritance of all traits, & he knew it. Show both dominant & recessive traits in phenotype require multiple genes to fully express phenotype. There is an allele that determines the trait. Gene product of allele will mask the other allele. Irrespective of what we have at allele, no gene expression because no transcription. Some phenotypes where dominant and recessive both expressed.
