IMED2004 Study Guide - Final Guide: Hh Blood Group, Fucose, Transferase
Document Summary
Abo blood group antigens differ in terminal sugar (a, b) Ia & ib encode transferases (a & b) that add either a or b sugar to a common substrate, h. The h locus encodes for a different transferase, adds a fucose to a precursor, producing substrate h. Hh & hh individuals express functional fucosyl transferase. Abo blood group, different terminal sugar in their chain. A is different to b, o has no sugar. All rbc type: chain of glucose etc. If have big h allele at the locus (hh or hh) As a fucose, at the end of the chain. If have it, can add b or a sugar. Once substrate h is produced, the a & b transferases. If express a glysocyl transferase with substrate h attached. Can add a or b sugar to terminal chain. Most people at the h locus have the dominant h allele. Homozygotes for h (hh = bombay phenotype)
