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[BIOLOGY 1M03] - Midterm Exam Guide - Comprehensive Notes for the exam (33 pages long!)

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blackherring683
6 Feb 2017
School
McMaster University
Department
Biology
Course
BIOLOGY 1M03
Professor
Ben J Evans

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Related Questions

What are the three components of the cell theory?

Of what is the cell membrane is mainly composed?

TRUE or FALSE: A prokaryotic cell has a nucleus.

TRUE or FALSE: An eukaryotic cell does not have membrane-bounded organelles.

Most organelles can be found in both in plants and animals. What three organelles are unique to plants?

What organelles can only be found in animal cells?

Which of the following contains digestive enzymes?

TRUE or FALSE: In most mammals, the DNA found in mitochondria is inherited from the mother only.

TRUE or FALSE: Flagella are not found on eukaryotic cells.

How do phospholipids interact with water to form the cell membrane?

TRUE or FALSE: All living things have a plasma membrane and a cell wall.

What is the first law of thermodynamics?

What is the example of potential energy that was given in the lecture notes?

What is the second law of thermodynamics?

What is entropy?

What is an exergonic reaction?

What is an endergonic reaction?

TRUE or FALSE: An enzyume is an organic molecule (usually a protein) that catalyzes a cellular reaction.

How does an enzyme work?

What is the region of an enzyme that binds the substrate?

TRUE or FALSE: Phagocytosis is an example of bulk transport.

TRUE or FALSE: Osmosis involves the movement of water only.

What is competitive inhibition?

What is non-competitive inhibition?

What is the energy currency of our bodies?

How do particles move in passive transport?

How do particles move in active transport?

Which type of plastid stores starch?

The largest amount of DNA is localized to the ________ in both bacteria and archaea.

Which organelle creates the lysosome?

Which component of the endomembrane system modifies proteins?

Which is the hereditary material of life?

Which organelle contains digestive enzymes to break down ingested bacteria?

In non-competitive inhibition (allosteric regulation), where does the inhibitor bind?

According to the first law of thermodynamics, energy can neither be ________ nor ________ .

1. In addition to identifying the genetic material, the experiments of Avery, MacLeod, and McCarty with different strains of Streptococcus pneumoniae demonstrated that
DNA is a double helix.
DNA may be taken up by bacterial cells and be active.
DNA is present in bacteriophage T2.
eukaryotic cells may be genetically transformed.
DNA binds to the cell wall of the bacterium.
2. In order to show that DNA in cell extracts is responsible for genetic transformation in Streptococcus pneumoniae, important corroborating evidence should indicate that _______ also destroy transforming activity.
temperatures high enough to kill cells
enzymes that hydrolyze proteins
enzymes that hydrolyze DNA
enzymes that hydrolyze polysaccharides
enzymes that hydrolyze RNA
3. Based on what you have learned about the experiments conducted by Griffith and Avery and colleagues with bacteria, which of the following would result in transformation of living R cells?
Pure RNA from S cells
Cell-membrane extracts from S cells
A mixture of pure RNA and protein from S cells
Cell-free extracts from S cells
Pure protein from S cells
4. A-T base pairs in a DNA double helix
form three hydrogen bonds with each other.
are more heat-stable than G-C base pairs.
are of a substantially different length than G-C base pairs.
are not accessible to DNA binding proteins.
are chemically distinct from G-C base pairs.
5. If 23 percent of the bases in a sample of double-stranded DNA are adenine, what percentage of the bases are uracil?
27
50
0
73
23
6. The uniform diameter of the DNA structure provides evidence for
antiparallel DNA strands.
a right-handed helix.
a double-stranded helix.
3′ end phosphorylation.
purine–pyrimidine pairing.
7. If a sequence of one strand of DNA is 5′-TGACTATC-3′, what is the complementary strand?
5′-ACTGATAG-3′
3′-TGACTATC-5′
3′-ACTGATAG-5′
3′-ACTGATAG-3′
5′-TGACTATC-3′
8. What structural aspect of the DNA facilitates dissociation of the two DNA strands for replication?
3′ end phosphorylation
Purine–pyrimidine pairing
Antiparallel DNA strands
Covalent bonds between sugars and phosphate groups
Hydrogen bonding between paired bases
9. If the Meselson–Stahl density gradient experiment had resulted in two bands of DNA molecules after only one round of replication, one containing only 15N and the second only 14N, this result would have indicated that replication was
unidirectional.
dispersive.
conservative.
bidirectional.

semiconservative.
10. The nucleoside analogue acyclovir, which is used to treat herpes simplex virus (HSV) infections, lacks a 3′ hydroxyl group (–OH). Predict what will happen if the host cell DNA polymerase incorporates a molecule of acyclovir into an elongating strand of HSV DNA.
The replication complex will no longer bind to origins of replication.
The DNA polymerase will only incorporate acyclovir molecules.
Acyclovir will bind single-strand binding proteins.
DNA polymerase will not be able to link a successive nucleotide.
Acyclovir will block the activity of the DNA helicase.
11. Which of the following does not demonstrate the stability of the DNA double helix?
Single-strand binding proteins are required to keep the strands apart.
Paired bases form hydrogen bonds.
High temperatures are required to denature it.
DNA synthesis requires energy.
DNA helicases require ATP.
12. What effect would a primase inhibitor have on DNA replication?
DNA polymerase would not be able to add bases to the DNA.
Primase would be blocked from joining the DNA replication complex.
Primase would not be able to provide primers for DNA polymerases.
DNA polymerase would not be able to use DNA as a template.
There would be no effect on DNA replication.
13. To replicate their DNA in a timely manner, most eukaryotic chromosomes
normally have uncoiled DNA.
have multiple origins of replication.
contain linear molecules of single-stranded DNA.
have two replication forks that move in the same direction.
are composed entirely of DNA.
14. Which statement about DNA replication is false?
Okazaki fragments are synthesized as parts of the leading strand.
Error rates for DNA replication are reduced by proofreading of the DNA polymerase.
The sliding clamp increases the rate of DNA synthesis.
Replication forks represent areas of active DNA synthesis on the chromosomes.
Ligases and polymerases function in the vicinity of replication forks.
15. In many eukaryotes, there are repetitive sequences called telomeres at the ends of chromosomes. After successive rounds of DNA replication, the _______ strand becomes shorter. In some cells, an enzyme called _______ repairs the shortened strand.
leading; telomerase
lagging; telomerase
lagging; DNA polymerase I
leading; DNA polymerase I
leading; replicase
16. A researcher studies normal human fibroblast cells. They can be maintained in culture but die off after about 30 cell generations. Unexpectedly, a colony of cells continues to survive and divide past 30 generations. Which scenario is most likely true for these cells?
DNA polymerase is constantly active.
Primase is able to extend the telomeres.
The mismatch repair system is extra efficient.
The telomerase gene is being expressed.
The cells do not need the ends of their chromosomes.
17. If DNA polymerase III introduces an incorrect nucleotide, what is the first corrective action made by the DNA repair system?
The replication complex excises the incorrect nucleotide.
The excision repair proteins remove the incorrect nucleotide.
The mismatch repair system scans for base-pairing mismatches.
There is no correction, because nucleotide errors by DNA polymerases are not repaired.
DNA ligase connects the correct nucleotide.
18. Choose the correct order of the following four events in the excision repair of DNA:
(1) Base-paired DNA is made complementary to the template.
(2) Damaged bases are recognized.
(3) DNA ligase seals the new strand to existing DNA.
(4) Part of a single strand is excised.
1, 2, 3, 4
2, 1, 3, 4
3, 4, 2, 1
2, 4, 1, 3
4, 2, 3, 1
19. Six complete cycles of PCR should result in a _______-fold increase in the amount of DNA.
64
32
12
128
6
20. When double-stranded DNA is heated to temperatures above 90°C, it denatures. Denaturation is a process that
breaks covalent bonds.
hydrolyzes DNA.
separates double-stranded DNA into two single strands.
causes new hydrogen bonds to form.
irreversibly destroys the double helical structure.

Question 1


Which of the following provides the best description of adifference between prokaryotic and eukaryotic cells?.l.14.3>

The cell membrane of prokaryotic cells contains proteins, whilethe cell membrane of eukaryotic cells contains only lipids andcarbohydrates.

The DNA in eukaryotic cells is enclosed in the nucleus, whilethe DNA in prokaryotic cells is not separated from the rest of thecell’s contents.

Eukaryotic cells have cell walls that consist mainly of sugars,while prokaryotic cells do not.

Prokaryotic cells contain chloroplasts and mitochondria, whileeukaryotic cells do not contain specialized organelles.

Question 2

Cellular respiration is a process involving the breakdown ofglucose molecules in order to generate energy for cellularactivities. Given the general reaction below, which of thefollowing best describes the products labeled x andy?

C6H12O6 + O2 → _x___+ __y___ + energy.l.18.8>

The products are CO (carbon monoxide) andH2O2 (hydrogen peroxide), which thendecompose into carbon dioxide (CO2) and water(H2O).

The products are H2O (water) and CO2 (carbondioxide), which then undergo anaerobic respiration.

The products are CO2 (carbon dioxide) andH2O (water), which then become the reactants forphotosynthesis.

The products are O2 (oxygen) and H2O(water), which are then used for growth and to keep the organismhydrated.

Question 3

If a researcher added a quantity of phospholipid molecules to abeaker of water, what would be most likely to happen to theorientation of the phospholipid molecules?.l.14.2>

They would break apart, and the remaining lipid tails wouldfloat up and form a layer on the surface of the water.

Their lipid tails would align within a spherical double layerwith their phosphate heads in the water inside and outside thesphere.

They would form a single-layered sphere with the phosphate headspointing outward and the lipid tails pointing inward.

Their lipid tails would adhere to the glass of the beaker andtheir phosphate heads would float in the water.

Question 4

While looking at a cell under a microscope, a scientist is ableto see a biological molecule. This molecule is a nucleic acid witha ladder structure and contains the nitrogenous bases adenine,thymine, cytosine, and guanine. Based on this information, whatconclusion can the scientist draw regarding this nucleicacid?.l.18.1>

The nucleic acid is RNA and would be found in the cell’snucleus.

The nucleic acid is RNA and would be found in the cytoplasm.

The nucleic acid is DNA and would be found in the cytoplasm.

The nucleic acid is DNA and would be found in the cell’snucleus.

Question 5


Which of the following is needed for cellular respiration tooccur?.l.18.8>

Sodium

Oxygen

Water

Nitrogen

Question 6


What would be the most likely effect if the side chain of an aminoacid group was unable to vary its structure?.l.18.4>

The organism would not be able to make and store starches.

The organism would not be able to process glucose moleculeseffectively.

The organism would not be able to regulate the creation ofspecialized cells.

The organism would not be able to make more than one type ofprotein.

Question 7


During photosynthesis, unused oxygen atoms form oxygen gas(O2) which is released as a waste product. How did theseoxygen atoms originally enter the plant?.l.18.7>

They were part of the ATP molecules gathered by thechloroplasts.

They were part of the sugar molecules(C6H12O6) the plant brought in forfood.

They were part of the carbon dioxide (CO2) moleculesthat entered through the leaves.

They were part of the water molecules (H2O) pulled inthrough the roots.

Question 8


Which of the following organelles houses DNA in eukaryoticcells?.l.14.3>

Endoplasmic reticulum

Golgi apparatus

Nucleus

Mitochondrium

Question 9


M. J. Schleiden shifted the scientific community's attention tocellular processes with his.l.14.1>

attention to disproving spontaneous generation

publication of ideas on cell generation

theories on the division of cells

claim that cells were the basic unit of all plant matter

Question 10


While the average human is able to hold his or her breath forapproximately one minute, a whale can dive for over 30 minuteswithout returning to the surface. Which of the following correctlydescribes this difference?.l.18.10>

Whales need less energy than humans.

Whales gather energy from their environment better thanhumans.

Whales are able to tolerate the products of cellular respirationbetter than humans.

Whales have a slower cellular respiration metabolism rate thanhumans.

Question 11


What can you conclude about the advantage of the cell membranehaving hydrophobic ends in the phospholipid bilayer?.l.18.3>

The cell requires the ability to digest and eliminateenzymes.

The cell requires a barrier between itself and itsenvironment.

The cell requires a means to store starches and glucose.

The cell requires a structure for eliminating waste.

Question 12


What would be the most likely outcome if the ribosomes of a cellwere damaged and stopped functioning?.l.14.3>

The cell would lose structure and shape.

Cell growth and repair would slow or stop.

Cell waste would no longer be processed.

The cell would produce more mitochondria.