BIOLOGY 1P03 Study Guide - Alpha-Synuclein, Excitotoxicity, Globus Pallidus
23 Nov 2014
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Document Summary
Parkinsons is not yet understood neurologically involve events that include interaction between; genetic and environmental factors, abnormalities in protein processing, oxidative stress, mitochondrial dysfunction, excitotoxicity, inflammation, immune regulation, & other mechanisms. Treatment (amy lynch - 0847540) pharmacology o neuroprotective: theory based on concept that 3-4 thousand at-risk dopaminergic neurons in human substantia nigra can be protected from the complex degenerative process that causes premature cell death and depletion of dopamine. Levodopa o: mao b inhibitors: selegiline and rasagiline, dopamine agonists: pramipexole and ropinirole, bromocriptine + mao b inhibitor. Surgical o deep brain stimulation subthalamic nucleus versus globus pallidus dbs.
