HTHSCI 3I03 Midterm: Innate Immunity Midterm Study Notes
25 Mar 2015
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Document Summary
Possessed by all metazoans, immediate response, no memory, broad specificity. Prrs are receptors with a very limited repertoire. Prevents attachment or entry of pathogenic microbes, while allowing growth of beneficial ones. Recognize, control, and eliminate pathogens at the site of entry. Induce inflammation, bring help to site of infection. Orchestrate an appropriate, measured adaptive immune response. Occurs in jawed vertebrates, delayed response (5-7 days). Generates memory by randomly generated receptors multiplying in a clonal fashion. Epithelial surfaces provide the first line of defense. Keratinized to help prevent wetness: sebaceous glands produce fatty acids and make the skin acidic. ph of the dermis is 4, making the skin uninhabitable. Mucosa: wet epithelial surfaces: each are layered, and act as important selective barriers. urogenital. Normal flora: tight junctions and gap junctions provide a watertight seal. Gut microbiota prevent infections by competing for space and resources, and by producing antibacterial components. Bacteriocins, defensins, and cationic proteins directly kill bad bugs.
