LIFESCI 2N03 Study Guide - Final Guide: Christiaan Eijkman, Scurvy, Vitamin B6
12 Dec 2014
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Document Summary
3500 years ago, arabic and egyptian physicians provided foods to help with star-gazing at night. Followed the practice of arabic and egyptian physicians. Prescribed beef liver for star gazing (vitamin a) for night blindness. British physician - sailors, scurvy, lime, vitamin c. Produced beriberi in chicken, cured by brown rice not white due to. Beriberi impairs glucose metabolism, nervous system problems, muscle wasting. Isolated a nitrogen containing functional group amine in rice. Discovered that providing amine improved health of thiamine deprived chickens. Water soluble are urinated if not being used. Thiamin, riboflavin, niacin, pantothenic acid, biotin, folate, b6, b12. Absorbed directly through intestinal cells into the cv. Susceptible to filtration by urination we need to ingest more. Vitamin c deficiency symptoms manifest after 20-40 days. Toxicity is rate but b6 is the most concerning, very large window between rda and ul. Fat soluble vitamins are absorbed with dietary lipids. Efficiency of absorbing and using decreases with greater caloric ingestion.
