MOLBIOL 4P03 Study Guide - Midterm Guide: Lipid A, Type Three Secretion System, Streptococcus
27 Feb 2017
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Spread from new york in 1999 to ontario in 2000 to western provinces in 2003; outbreak in. Oakville/burlington in 2002, infection rate 50x higher than toronto. Natural host is birds; mosquitoes transmit from bird to bird and to humans. First detected in china 2002; by 2003, over 8089 cases and 800 deaths worldwide. Animal-human transmission due to the practice of trapping exotic animals in china. Responsible for all pandemics: influenza b found only in humans; b and c do not affect domestic animals, influenza c causes mild infections; does not cause epidemics. 1918-19 spanish flu (a, h1n1) caused 20-40 million deaths. 1957-58 asian flu (a, h2n2) killed 70,000 in us; emerged from china and spread to north america. 1968-1969 hong kong flu (a, h3n2) caused 35,000 deaths in us. Features of pandemic all influenza viruses mutate continuously. Aiv mutate to acquire ability to infect humans; little or no immunity present leading to pandemic as infection spreads horizontally.
