BIOL 103 Study Guide - Final Guide: Aids, Memory T Cell, Antigen-Presenting Cell
24 Jul 2016
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Document Summary
Oncogenic (cancer causing) viruses (can contain single stranded dna or rna) Retrovirus: rna virus that can integrate into the host dna. Human immunodeficiency virus (hiv) and acquired immune deficiency syndrome (aids) Spread by transfer of white blood cells from one infected person to another. Hiv enters helper t cells, using cd4 proteins as receptors. Once glycoproteins on envelope (gp120) bind to cd4, conformational change allows gp120 to interact with chemokine co-receptors, gp120 enters host cell and two membranes (viral and host cell) fuse. Hiv also enters other cells such as antigen presenting cells, cells lining digestive tract and microglial cells. Life cycle: virus fuses with cell"s plasma membrane, capsid proteins are removed releasing viral proteins and. Rna: reverse transcriptase catalyzes synthesis of dna strand complementary to viral rna, also second. Meanwhile the patient makes antibodies to hiv"s gp120s and is now considered hiv+ Hiv proviruse can hide" in target cells including memory t cells.
