MICR 360 Study Guide - Midterm Guide: Memory B Cell, Affinity Maturation, Mhc Class Ii

• School: Queen's University
• Department: Microbiology and Immunology
• Course: MICR 360
• Professor: Sameh Basta

Document Summary

B cell present ag to helper t cell which act b cell prolif + diff plasma (secretes ab) or memory b cell and may undergo class switching + affinity maturation in 2 lymphoid organs. 1 ab response: na ve mature b cell responds. Lag period, low ab conc + affinity, igm mainly. No lag, higher conc + ab affinity, mainly igg less igm: ag binds memb ab iga-igb induces intracell signaling cascade to incr mhc ii + b7 exp then ag-ab internalized and presented on. Mhc ii: th rec ag, b7-cd28 act th cell and cd40l bind cd40 to induce nf- kb transcription + exp of cytokine r on b cell, cytokine binds rs on b cell to induce prolif + diff. Type i: ag binds mitogen r + possibly bcr polyclonal act ab not specific for ti-1 ag, mainly igm w no memory response ex.