PHAR 340 Study Guide - Final Guide: Vascular Smooth Muscle, Decongestant, Cardiogenic Shock

• School: Queen's University
• Department: Pharmacology and Toxicology
• Course: PHAR 340
• Professor: Thomas Massey

Document Summary

B3 b/n autonomic pre and post gang, stim e from adrenal medulla. Gi, inhibits ca influx + nt release, vasoconstriction. Gs, incr hr, renin, presynaptic facilitation (incr effect of pre on postsynaptic neuron) Gs, relaxes bronchial, uterine + gi smooth muscle, dilates vascular smooth, immunosuppression. Adrenal medulla, relax uterus, gi + resp tract via b2. B1 incr hr + bp, a1/2 cause vasoconstriction + incr bp. B1 incr hr + bp, b2 vasodilation=decr bp. Cardiac m2 decr hr, m3 cause vasodilation (no) Incr hr + bp, nausea, diarrhea, depresses auto ganglia transmission. Blocks pns + sns, pns tone is larger so decr bp. Iv injection of 2 tnf r linked by igg. Binds + destroys b cells when binding cd20. Carbamazepine anti-convulsant, interferes w na chans in brain. Metab into alloxanthine which inhibits xanthine oxidase preventing uric acid formation. Probenecid + sulfinpyrazone, inhibit renal tubular reabsorption of uric acid. Metab via ugt, assoc w birth defects + gum overgrowth.