NURS 116 Study Guide - Final Guide: Opportunistic Infection, Hives, Infection
14 Apr 2019
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Document Summary
3 ways to prolong drug activity used to decrease the rate of absorption: use of probenecid (decrease excretion) , epinephrine or peolythian-acid (a molecule, extended release drugs, recirculation from the gi tract, affecting drug solubility (lipid solubility preferred) Effect first pass metabolism has on oral dosing vs iv: increased dosing. Pharmacokinetic impacts of low lipid solubility: decreased distribution due to less active transport being accomplished across cell membranes. High plasma protein beneficial property: increased half life. Most common drug effects on pathogens: inhibits cell replication and causes the lysis of cell wall membranes. Post transplant: minimize rejection as close as to 100% as possible. Hiv: to prevent as much viral resistance as possible and keeping the viral load as small as possible. Severe systemic infection: lowers systemic adverse effects and allows us to lower doses on certain medications, while also providing broad spectrum in cases where the cause of infection if unknown and prevents resistance.
