PATH 3610 Study Guide - Final Guide: Carcinogenesis, Hyperplasia, Cellular Differentiation

• School: University of Guelph
• Department: Pathology
• Course: PATH 3610
• Professor: Andrew Vince

Document Summary

Disturbances of growth can lead to either an increase of decrease in the mass of the affected tissue; many of these changes are initiated as a cellular response or adaptation to injury: hyperplasia. Pathologic hyperplasia is a non-physiologic response; most forms of pathologic hyperplasia result from excessive hormonal or growth factor stimulation. Examples of pathological hyperplasia include: in endometrium due to increased hormone, wound healing. Hypertrophy is the only method of adaptation that can occur in tissues made up of permanent cells, in which increased functional demand cannot be met by cell multiplication. Atrophy can have a variety of causes than formation: disuse atrophy. Result of lack of use of muscles. A rapid decrease in the size of the muscle cells (fibres); can be reversed quickly when activity is resume with time, however, the numbers of muscle cells also decreases: denervation atrophy. Result of lack of stimulation of muscle fibres by lower motor neurons.