Biochemistry 2280A Study Guide - Midterm Guide: Crosslinks, Hydroxy Group, B Cell

• School: Western University
• Department: Biochemistry
• Course: Biochemistry 2280A
• Professor: Chris Brandl

Document Summary

Detects signals and transmits them to the cell. Binds to dna to switch genes on or off. Lipid-binding proteins: ma(cid:374)(cid:455) protei(cid:374)s (cid:272)o(cid:374)tai(cid:374) sites to (cid:449)hi(cid:272)h liga(cid:374)ds spe(cid:272)ifi(cid:272)all(cid:455) (cid:271)i(cid:374)d a(cid:374)d for(cid:373) a (cid:862)(cid:272)o(cid:373)ple(cid:454)(cid:863) (cid:449)ith the protein, e. g. enzyme: substrate binding site/active site. [(cid:1867)(cid:1857)(cid:1866) (cid:1838)(cid:1859)(cid:1866)(cid:1856) (cid:1855)(cid:1867)(cid:1865)(cid:1868)(cid:1864)(cid:1857): e. g. hemoglobin: fe = ligand in the center bonds with n, calmodulin/ca2+ - 0. 1 m (10^-6 m, antibody/antigen - m ~ pm (10^-12 m, estrogen/estrogen receptor - m, biotin-streptavidin 1. 0 fm (10^-15) 000 (big: 28 polypeptide chains, uses atp to unfold proteins, ribosomal complex (ribosome): rna, proteins, and trnas. Forms strong fibers and sheets: most common protein in animals, extracellular - forms very strong fibrils that strengthen bone, skin and basement membranes of arteries, veins, and other tissues. Lack of vitamin c (ascorbic acid) in diet: needed for enzyme that hydroxylates p, non-hydroxylated prolines = unstable collage, osteogenesis imperfecta, often g mutations, prevent proper assembly of triple helix.