Biochemistry 3381A Study Guide - Quiz Guide: Integrin, Membrane Protein, Cytoskeleton
27 May 2020
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Document Summary
Cells held together within the extracellular matrix, a complex network of proteins and polysaccharide chains that the cells secrete. Cell movement in organism is governed by the remodelling of the ecm- guiding the cells while growing. Cell"s attachment to ecm controls the orientation of the cell"s cytoskeleton allowing the cell"s movement, thereby allowing cells to sense and respond to changes in the mechanical features of their environment. An integrin molecule is composed of two noncovalently associated glycoprotein subunits called and . Specificity of binding b/w ecm protein and integrins- same integrin molecule in different cell types can have different ligand-binding specificities, it seems that additional cell-type-specific factors can interact with integrins to modulate their binding activity. The binding of integrins to their matrix ligands is also affected by the concentration of ca2+ and mg2+ in the extracellular medium. Carbohydrate-rich region (glycoprotein and glycolipid) on the cell membrane. Proteoglycans- proteins binded with glycosaminoglycans (gag-unbranched polysaccharide chains composed of repeating disaccharides).
