Biochemistry 3381A Study Guide - Quiz Guide: Leishmania Major, Kinetoplast, Leishmania
27 May 2020
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Human intervention: altered pattern of toxoplasma + leishmania. Phylogenetic diversity: excavata kinetoplasta leishmania major, chromalveolata apicocomplexa- t gondii. 3 /6 major lineages (i. e. more diverse than helminths all multicellular animals) Evolution: host immunity, ecology, for replication in host, transmission between (definitive, intermediate, vector) No classical meiosis thus no definitive host. Hence cycles between vector and many mammalian hosts host determined by feeding of vector (some host preference sandfly species dependent. Has cycle within intermediate hosts determine geography. Sea ottwers never contact land animals e. g. cat still infected. 400 ad mexico; kala azar africa 1700s. Distribution- sandfly habitats: tropical, subtropical, some temperate: spain, middle east, mongolia, china. Promastigote: elongated, 1 flagellum, attached by axoneme, basal body, near basal body kinetoplast dna containing structure in single mitochondrion, also nucleus (distinct from kinetoplast, light microscopy detection (with stain) Amastigote: ovoid, aflagellate, but still have basal body + axoneme = kinetoplast proximal. Sandfly vector: elongated, flagellate, promastigotes, develop sandfly midgut.
