Biochemistry 3381A Study Guide - Quiz Guide: Tropical Eosinophilia, Microfilaria, Loa Loa

• School: Western University
• Department: Biochemistry
• Course: Biochemistry 3381A
• Professor: Brian Shilton

Document Summary

Lymphatic maturation up to a year: mating female microfilariae shedding. Immune suppressive factor secretion: most hosts hyporesponsive > filarial ag even w. circulating microfilariae. Diethylcarbazamine (dec) kill microfilariae but not adults can"t stop source. Adult subcutaneous migration: subcutaneous microfilariae deposition. Microfilariae > blood deerfly transmission: diurnal but reverse peripheral during day. May see migration microfilariae across subconjunctival space. Immunosuppression via gr alpha receptor, reduce il-1, tnf, cox, inos transcription, increase a1, ikb prevent strong th1 type. Dec kills both microfilariae + adults wont access all: but even asymptomatic v high worm burden, plus can"t treat w. o. volvulus co-infection > mazzotti reaction, plus ivermectin to treat volvulus > allergic encephalopathy. Can kill microfilariae, but adults unaffected could continue producing: plus death > immunopathology, e. g. Ivermectin highly effective against volvulus + loa loa; high loa loa microfilaria burden may trigger immune encephalopathy. Distinct metabolism to roundworms: surface nutrient absorption not true gut.