Biochemistry 3381A Study Guide - Quiz Guide: Volvulus, Artemisinin, Oxidative Stress

• School: Western University
• Department: Biochemistry
• Course: Biochemistry 3381A
• Professor: Brian Shilton

Document Summary

Impaired replication in rbc evolved to normal: affected water potential / [solute, reduced pfemps, reduced parasitaemia. Improved immunity acquisition: lowered symptoms splenic clearance hence disease genes maintained. G6pd deficiency: g6pd produces reducing power > atp, plus glutathione reduce free radicals, more oxidative stress esp. in hb, x linked obvious in males. Thalassemia: abnormal haemoglobin production: alpha abnormal alpha globin, reduced cytoadherence pathology i. e. rosetting / sequestration, less anaemia, protects against multiple plasmodium species, beta, better splenic removal infected, reduced invasion + growth, reduced cytoadherence pathology. P vivax no longer in fens / schistosomiasis in japan / malaria eastern us: us malaria: vector control primarily, + drainage, sanitation, hygiene, current progress on river blindness / malaria: chemotherapy + vector control. Vaccination: possible when long lived complete immunity virus sufficiently conserved > herd immunity > break transmission cycle: allowed elimination smallpox, polio control. Curing individuals prevent further transmission for period break transmission cycle: when mass vaccination impossible / not feasible.