Biochemistry 3381A Study Guide - Quiz Guide: Tubulin, Uncoupling Protein, Fumaric Acid

• School: Western University
• Department: Biochemistry
• Course: Biochemistry 3381A
• Professor: Brian Shilton

Document Summary

Closantel: uncoupling protein (h+ gradient dissipation: selectivity by uptake bind plasma proteins ingested by blood-sucking helminths, can"t produce atp released as heat. Clorsulon: inhibit phosphoglycerate kinase and mutase > inhibit glycolysis: selectivity by accumulation bind plasma proteins accumulated in blood-sucking helminth. Microtubules: prevent vesicle trafficking, structural integrity, chromosome segregation @ mitosis; also deplete nutrient uptake. Nb unusual for anthelmintic to be broad spectrum varied metabolism. Levamisole / pyrantel: spastic paralysis nicotinic agonists: cause muscle contraction nachr agonists. Praziquantel: membrane permeability increase ca influx: broad spectrum against schistomes multiple stages of life cycle, few side effects enhances immune response no host stuff targeted, produce small holes vulnerable to ab (esp. Ige) attachment: also disrupt cuticle prevent its immunosuppressive function (and greater penetrance of other drugs ?, e. g. schistosomiasis, flukes, tapeworms, cysticercosis, hydatid. Schistosomiasis: ancient issue described in egyptian papyrus. 3 schistosoma: cause bladder or intestinal: s. haematobium, bladder, s. japonicum.