[Biology 2581B] - Final Exam Guide - Everything you need to know! (37 pages long)
29 Nov 2016
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Document Summary
Almost every genome has equivalent amount and type of info. With mouse and human you have to break the mouse genome in 100s of fragments to align with human genome. Syntenic segments - same genes in the same order, transcribed in the same orientation. Constant regions of the chromosome - backbone of the antibody. Recombination events in different cells change the variable regions that are transcribed. Can lead to shift in formation of t and b cell clones, immune system can"t respond well. Large deletions result in loss of 10s or 100s of genes. Can be caused by x-ray or other chromosome damaging events that break dna backbone. Primers must be outside the deleted area. If deletions are large enough we can use karyotyping to see banding patterns in chromosomes, find what"s lost. Humans can"t survive of more than 3% of genome is deleted. Rearrangements of chromosome sequences to make different antibodies.
