Biology 3316A/B Study Guide - Final Guide: Aurora Kinase, Myelin, Zbp1

• School: Western University
• Department: Biology
• Course: Biology 3316A/B
• Professor: Anne Simon

Document Summary

2 types of neurotransmitter: small-molecule (high frequency) and neuropeptide (low freq) small-molecule (clear) slow axonal transport, neuropeptide (black) fast axonal transport. Slow transport observed by visualizing movement of a single neurofilament using nf-gfp. Glutamate is excitatory, binds to ampa or nmda receptors, sodium diffuses across synapse. Receptors must be transported to synapses, unc-116/kif5 transports ampars. In axon cell body, mrna of interest bound to mrna binding protein walk along mt (kinesin), then gets shuttled along actin (myosin) to allow local translation in dendritic spine. Synaptic plasticity due to cytoskeletal remodeling via beta-actin, involved in memory. Ltd aurora kinase a phosphorylates cpeb1 irsp53 reduced signaling to dendrite. Gc turning regulated by local b-actin mrna translation, transport of b-actin mrna via zbp1. Gcattract: netrin1, bdnf gcrepulse: sema3a, slit2 (local translation actin depolym prot) Injury ranbp1+importin-b1 translated bind to dynein, remove ran from dynein, activating dynein.