Microbiology and Immunology 2500A/B Final: Viriology Final Notes.doc
13 Feb 2015
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Document Summary
Measles: aerosols via cough + sneezes: highly contagious, vaccination has made it less prevalent in canada, highly contagious. Endogenous retroviruses integrated in our genome (e. g. hervs: not exogenous retroviruses (e. g. hiv) Major themes in virology: obligate molecular parasites can only function after it replicates in host cell, must make mrna that can be translated by host ribosomes, can"t translate themselves. They replicate -> means they can mutate: balance between evading host immune system and killing host, molecular clock. Tobacco mosaic virus: filtrate from tmv infected leaves, except mimivirus. See viruses with electron microscopy and modern structural biology. Mimivirus can be seen with light microscopy: does not pass through filter, amoeba host. Host cell machinery: energy, transport vesicles, protein translation mechanisms. Virus replication: absorption, attachment (shortest, eclipse, time when infectivity disappears, due to uncoating (longest) Latent: replication of genome, protein synthesis, maturation, assembly of genome + viral protein synthesis. Cell that takes up virus (susceptible) and allows virus to replicate (permissive)
