Microbiology and Immunology 3300B Midterm: Immunology 3300B Midterm 2 Notes

• School: Western University
• Department: Microbiology and Immunology
• Course: Microbiology and Immunology 3300B
• Professor: Rodney Dekoter

Document Summary

Lecture 10 immunologlobulins 1: structure, function, and v(d)j rearrangement. There are variable light and variable heavy chain: all these domains are referred to as immunoglobulin domains because it is from study of these proteins that this domains. type of protein domain was discovered. Many different proteins have an ig domain like structure. Immunoglobulin domains have antiparallel beta strand arrangement: which part of the ab is involved in interactions with ag? rolled into a barrel like structure, figure = light chain (could be lambda or kappa). There is a constant and a variable domain on the light chain: constant domain = 7 anti-parallel beta strands that make a beta pleated sheet. The antiparallel beta strands are: variable domain = 9 anti-parallel beta strands that make a beta pleated sheet. Also rolled into a barrel like structure: variable region interacts with antigens.