Pharmacology 2060A/B Study Guide - Final Guide: Dysthymia, Rate Limiting, Posttraumatic Stress Disorder
4 Jan 2017
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Dna by adding an alkyl group to cancer cell"s dna. Specifically they form a cross bridge between nitrogen atoms on guanine nucleotides. They act by cross linking dna and binding to guanine nucleotides. They act by inhibiting a particular enzyme that prevents dna replication from occurring. Kill cancer cells by intercalating dna, they move between the bases of dna to bind to dna. Block the process of mitosis during metaphase by binding to tubulin, disrupting organization, leading to cell death. Act in the late g2 phase, prior to. They stabilize the microtubules preventing cell division: hodgkins disease, solid tumors in head neck breast and ovary. Cyclophosphamide is a prodrug, and must be converted in the liver, this may delay its onset of action. Non cell cycle specific: ovarian cancer, testicular cancer, bladder cancer. Cell phase non specific: nephrotoxic, ototoxic, emetogenic. They are structurally similar to natural compounds in the body. S phase specific sever bone marrow surpression cardiotoxicicty.
