Pharmacology 2060A/B Study Guide - Midterm Guide: Hydrolysis, Microgram, Horse Length
30 May 2016
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Pharmacokinetics: what the body does to the drug: Oral drug dissolves in intestine, pass through enterocytes into the blood stream, a lot of. All inter-related factors that are important in determining how a drug will be absorbed. Large surface area means increase absorption, high concentration gradient, drug will be absorbed faster. Lipophilic drugs can directly cross the membrane can distribute to different tissues of the body. 1 microgram= 1000 nanograms all these values are important all values should be in same units before starting. A drug with a high vd has a very low plasma concentration, when plasma concentration is decreased, so the value of vd increases. All these values refer to a 70 kg person, if the kg changes, l changes but % is the same. Vd > 4l drug can leave the plasma. Vd < 14 l (plasma and interstitial volume) drug has not entered the intracellular fluid.
